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|Author||: David Servan-Schreiber|
|Editor||: Penguin Books|
The revolutionary, New York Times bestselling guide to the powerful lifestyle changes that fight and prevent cancer--an integrative approach based on the latest scientific research "A common-sense blueprint for healthy living." --Chicago Tribune "Resonating with cancer support communities and recommended nationwide." --Los Angeles Times "Life affirming . . . filled with practical advice." --The Seattle Times David Servan-Schreiber was a rising neuroscientist with his own brain imaging laboratory when, in the middle of an equipment test, he discovered a tumor the size of a walnut in his own brain. Forced to confront what medicine knows about cancer, and all that we still do not know, Servan-Schreiber marshaled his will to live and set out to understand the complex inner workings of the body's natural cancer-fighting capabilities. He soon found himself on a decades-long journey from disease and relapse into scientific exploration and, finally, a new view of health. Anticancer is at once the moving story of one doctor's inner and outer search for wellness and a radical exposition of the roles that lifestyle, environment, and trauma play in our health. Drawing on the latest research in integrative medicine that blends conventional and alternative approaches, Servan-Schreiber concisely explains what makes cancer cells thrive, what inhibits them, and how we can empower ourselves to prevent their growth. His advice details how to develop a science-based anticancer diet (and the small changes that can make a big difference); how to reap the benefits of exercise, yoga, and meditation; which toxic, unsafe products to replace in your home; and how to stave off the effects of helplessness and unhealed wounds to regain balance. Anticancer's synthesis of science and personal experience marks a transformation in the way we understand and confront cancer. A long-running bestseller that has changed the lives of millions around the world, Anticancer remains a pioneering and peerless resource, an inspirational and revolutionary guide to "a new way of life."
|Author||: Lorenzo Cohen PhD,Alison Jefferies, MEd|
“An invaluable guide for both professionals in the health field and the general public.” —Deepak Chopra, MD The evidence is in: you can reduce cancer risk and support treatment by focusing on six key areas of health and wellness. The scientific data on the link between lifestyle, environmental factors, and cancer risk has been accumulating at an accelerated rate over the past decade: Every week we learn something more that we can do as individuals to decrease the risk of cancer and improve the likelihood of long-term survival. Many of us—patients and doctors included—do not realize that changes in our daily choices and habits can improve quality of life, increase the chances of survival, and aid in the healing process for those with a diagnosis. These ideas were pioneered in David Servan-Schreiber’s Anticancer: A New Way of Life, and became the basis for a research study developed by Lorenzo Cohen and Servan-Schreiber at The University of Texas MD Anderson Cancer Center. Introducing the concept of the “Mix of Six,” Cohen and Alison Jefferies make an informed case that building social and emotional support; managing stress; improving sleep, exercise, and diet; and minimizing exposure to environmental toxins work together to promote an optimal environment for health and well-being. While each plays an independent role, the synergy created by all six factors can radically transform health; delay or prevent many cancers; support conventional treatments; and significantly improve quality of life—as many testimonies and stories of those in the anticancer community eloquently show. Anticancer Living provides an accessible, prescriptive guide to wellness based on the latest scientific findings and clinical trials, and it showcases the community of doctors, researchers, caregivers, and patients who have been inspired to create change.
|Author||: Bruce C. Baguley,David J. Kerr|
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching
|Author||: Beverly A. Teicher|
|Editor||: Springer Science & Business Media|
Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest, detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing, explain the criteria for success, and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.
|Author||: Alex A. Adjei,John K. Buolamwini|
|Editor||: Academic Press|
This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *
|Author||: Soodabeh Saeidnia|
This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
|Author||: Ester Heath,Marina Isidori,Tina Kosjek,Metka Filipič|
|Editor||: Springer Nature|
The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.
|Author||: Lorenzo Cohen,Alison Jefferies|
The revolutionary, science-based plan to reclaim your health"You have cancer." These are perhaps the most feared three words that will ever come out of a doctor?s mouth, and more and more people are hearing them. Yet most patients (and some doctors) do not realize that lifestyle changes can dramatically reduce risk, assist treatment and improve chances of surviving and even thriving after a diagnosis. Over the course of a major study Servan-Schreiber designed with Dr Lorenzo Cohen at the MD Anderson Cancer Center, six key areas have emerged- love and social support, stress management, rest, movement, nutrition and avoiding environmental toxins. Each plays a role--but it's the synergies created by this potent "Mix of Six" that can bring about real shifts in health and well-being, significantly improving quality of life and positively supporting conventional cancer treatments.Dr. David Servan-Schreiber's Anticancer introduced a revolutionary way to understand and confront cancer, changing the lives of millions around the world. He laid out the principles of integrative care that had allowed him to live many years beyond expectations for his own cancer, but readers have long requested a specific plan to implement his approach. Anticancer Living is that book.
|Author||: David Khayat|
|Editor||: W. W. Norton & Company|
With the huge number of studies on nutrition and cancer available, it's impossible for a person to sort through them all to come up with practical recommendations. Now, Dr. David Khayat, a world-renowned oncologist, has done that hard work for you. In this international bestseller, Dr. Khayat provides easy-to-follow—and often surprising—guidelines on what are now known to be the foods most likely to reduce the risk of cancer. For those of a scientific bent, he explains what cancer is and how it develops. Bringing together his own research with that of other major cancer specialists, he breaks down what the studies mean, which ones provide the most solid evidence, and how to use their results in your and your family’s diet. Structured by the major food groups—as well as supplements, beverages, and exercise—The Anticancer Diet may surprise you by not disparaging red meat but alerting you to find out the source of your fish and suggesting sole over salmon. While highly recommending commercial pomegranate juice, it cautions people with fair hair and eyes against drinking orange juice. What stage of life a person is at will also affect what they should consume. Pregnant women, older women, men, and children may process foods differently. With numerous easy-to-read charts and tables along with a comprehensive food list at the back of the book, this accessible, user-friendly guide helps readers realize the power in their everyday choices.
|Author||: Adam Todd,Paul W. Groundwater,Jason H. Gill|
|Editor||: John Wiley & Sons|
An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
|Author||: Loutfy H. Madkour|
|Editor||: Academic Press|
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy
|Author||: Niamh M O’Boyle,Mary J Meegan|
The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.
|Author||: Akhileshwar Kumar Srivastava,Vinod Kumar Kannaujiya,Rajesh Kumar Singh,Divya Singh|
|Editor||: Academic Press|
Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients. This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical field interested in understanding more about natural products with anticancer potential. Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites
|Author||: David E. Thurston|
|Editor||: CRC Press|
While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals. The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides some relevant information on side effects, dosing, and formulation. The author, a renowned scientist in cancer research and drug development, also provides up-to-date information on the drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of personalized medicine (e.g., oncogenomics) and chemoprevention. Chemistry and Pharmacology of Anticancer Drugsis an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments. Its breadth of coverage also makes it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, and related disciplines.
|Author||: William B. Pratt,William D. Ensminger,Raymond W. Ruddon|
|Editor||: Oxford University Press, USA|
This is an up-to-date review of the pharmacology, mechanisms of action, development of resistance, and toxicity of cancer chemotherapeutic agents. A rationale for their clinical use, based on cancer cell biology, is given for each class of drugs.
|Author||: Sotiris Missailidis|
|Editor||: John Wiley & Sons|
Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.
|Author||: Michelle Prudhomme|
|Editor||: Bentham Science Publishers|
Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.
|Author||: Patrizio Lancellotti,Jose L Zamorano,Maurizio Galderisi|
|Editor||: Academic Press|
Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment