Interferon Alpha 2  Pre Clinical and Clinical Evaluation

Interferon Alpha 2 Pre Clinical and Clinical Evaluation

  • Publisher : Springer Science & Business Media
  • Author : Daniel L. Kisner
  • ISBN-10 : 9781461325796
  • Release : 2012-12-06
  • Genre: Medical
  • Download/Read : 112
  • Price : FREE
E-book Explanation:

Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramus cular and subcutaneous routes. Clinical toxicity principally involves the 'influen za like' syndrome previously seen with native interferons. Other important toxi cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in non Hodgkin's lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi's sarcoma, with suggestions of activity in Hodgkin's disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these disea ses are now warranted in populations of patients with as little bulk disease and prior treatment as is feasible for each tumour type. This is particularly the case in . Hodgkin's disease and subcategories of the non-Hodgkin's lymphomas. Alterna tely, interferon alpha-2 might be used to maintain remissions induced by other modalities (i. e. , in NHL, multiple myeloma, ovarian cancer). In some advanced disease settings, combinations of interferon alpha-2 with chemotherapeutic agents should now be investigated.

Evaluation of the Voluntary National Tests  Year 2

Evaluation of the Voluntary National Tests Year 2

  • Publisher : National Academies Press
  • Author : National Research Council
  • ISBN-10 : 0309184282
  • Release : 1999-11-17
  • Genre: Education
  • Download/Read : 110
  • Price : FREE
E-book Explanation:

In his 1997 State of the Union address, President Clinton announced a federal initiative to develop tests of 4th-grade reading and 8th-grade mathematics that could be administered on a voluntary basis by states and school districts beginning in spring 1999. The principal purpose of the Voluntary National Tests (VNT) is to provide parents and teachers with systematic and reliable information about the verbal and quantitative skills that students have achieved at two key points in their educational careers. The U.S. Department of Education anticipated that this information would serve as a catalyst for continued school improvement, by focusing parental and community attention on achievement and by providing an additional tool to hold school systems accountable for their students' performance in relation to nationwide standards. Shortly after initial development work on the VNT, Congress transferred responsibility for VNT policies, direction, and guidelines from the department to the National Assessment Governing Board (NAGB, the governing body for the National Assessment of Educational Progress). Test development activities were to continue, but Congress prohibited pilot and field testing and operational use of the VNT pending further consideration. At the same time, Congress called on the National Research Council (NRC) to assess the VNT development activities. Since the evaluation began, the NRC has issued three reports on VNT development: an interim and final report on the first year's work and an interim report earlier on this second year's work. This final report includes the findings and recommendations from the interim report, modified by new information and analysis, and presents our overall conclusions and recommendations regarding the VNT.

Evaluation and Aid Effectiveness No 2   Evaluating Country Programmes Vienna Workshop  1999

Evaluation and Aid Effectiveness No 2 Evaluating Country Programmes Vienna Workshop 1999

  • Publisher : OECD Publishing
  • Author : OECD
  • ISBN-10 : 9789264033825
  • Release : 2001-12-10
  • Genre:
  • Download/Read : 272
  • Price : FREE
E-book Explanation:

Evaluation is a key tool in improving the quality and effectiveness of development co-operation. The Development Assistance Committee (DAC) Working Party in Aid Evaluation is the only international forum where bilateral and multilateral evaluation ...

A New Approach in Type 2 Diabetes Mellitus Treatment  Evaluation of the Beneficial Effect of L cysteine in the Treatment of Type 2 Diabetes Mellitus

A New Approach in Type 2 Diabetes Mellitus Treatment Evaluation of the Beneficial Effect of L cysteine in the Treatment of Type 2 Diabetes Mellitus

  • Publisher : Anchor Academic Publishing (aap_verlag)
  • Author : Mennatallah Ali
  • ISBN-10 : 9783954893539
  • Release : 2015-01
  • Genre: Medical
  • Download/Read : 248
  • Price : FREE
E-book Explanation:

Type 2 diabetes mellitus (T2DM) is a chronic, progressive metabolic disease characterized by chronic hyperglycemia. Although its main physiological abnormalities are insulin resistance and impaired insulin secretion, the specific underlying determinants of these metabolic defects remain uncertain. There are complex interactions between genetic, epigenetic, environmental and behavioral factors that contribute to the development of diabetes. Non-pharmacological and pharmacological interventions have been used for diabetic management. Over the past few years, research has started to focus on the use of novel adjuvant drugs as antioxidants and anti-inflammatory drugs for better management, as it was revealed that both oxidative stress and inflammation play a critical role in the disease pathogenesis. Thus, the development of antidiabetic drugs that can reverse insulin resistance is a potential therapeutic target. Although antidiabetic drugs may be effective in improving glycemic control, they do not appear to be effective in entirely preventing the progression of pancreatic ß-cells damage mediated by chronic hyperglycemia-induced decline in intracellular antioxidants. Therefore, antioxidant and anti-inflammatory therapy should be considered as an adjunct to the commonly used oral antidiabetics

Electromagnetic Nondestructive Evaluation  II

Electromagnetic Nondestructive Evaluation II

  • Publisher : IOS Press
  • Author : R. Albanese
  • ISBN-10 : 9051993757
  • Release : 1998
  • Genre: Technology & Engineering
  • Download/Read : 344
  • Price : FREE
E-book Explanation:

Europe's place in the world throughout the narrative and in the primary source feature, 'The Global Record.' The seventh edition has been carefully revised and edited for greater accessibility, and features a streamlined design that incorporates pedagogical features such as focus questions, key terms, and section summaries to better support students of western civilization. The reconceived narrative and restructured organization, featuring smaller, more cohesive learning units, lend to greater ease of use for both students and instructors. History CourseMate, a set of media-rich study tools with interactive eBook that gives students access to quizzes, flashcards, primary sources, videos and more, are available for this new edition. (CourseMate may be bundled with the text or purchased separately.) Available in the following split options: WESTERN CIVILIZATION: BEYOND BOUNDARIES, Seventh Edition Complete, Volume I: To 1715, Volume II: Since 1560, Volume A: To 1500, Volume B: 1300-1815, and Volume C: Since 1789. Available with InfoTrac Student Collections http://gocengage.com/infotrac.

Evaluation in Planning

Evaluation in Planning

  • Publisher : Springer Science & Business Media
  • Author : Nathaniel Lichfield
  • ISBN-10 : 9789401714952
  • Release : 2013-03-09
  • Genre: Social Science
  • Download/Read : 384
  • Price : FREE
E-book Explanation:

This book is the result of a three day workshop on "Evaluation in theory and practice in spatial planning" held in Ramsey Hall, University College London, in September 1996. Some 30 people from 8 different countries attended and 20 papers were presented. The majority of them now form the basis for this book. This occasion was the third on the topic, the two preceding having taken place in Umea in June 1992 and in Bari in 1994. Following these three meetings, we can now say that this small, industrious, international family really enjoy meeting up from time to time at each others places, in the presence of older members and new children, each one presenting his/her own recent experiences. It particularly enjoys exchanging views and arguing about the current state and the future of evaluation in spatial planning (all families have their vices ... ). It is also pleasing to see these experiences and discussions resulting in a book for those who could not attend and for the broader clan in the field. Not long time ago, but ages in the accelerated academic time scale, evaluation in planning established its own role and distinct features as an instrument for helping the decision-making process. Now this role and these features are exposed to major challenges. First, the evolution of planning theory has lead to the conception of new planning paradigms, based on theories of complexity and communicative rationality.